They finished the group engagements with four wins, one defeat, and a draw and topped the pool with 13 points, two more than the reigning champions, the Red Devils.
Simba will hope to maintain the solidity they showed in the group stage, where they only conceded two goals and kept four clean sheets as goalkeepers Aishi Manula and Beno Kakolanya were used between the sticks.
Mozambique winger Luis Miquissone - who scored a clinical goal against Al Ahly in matchday three to earn Simba a surprise 1-0 win - is expected to be the club's creative brain during the knockout stage.