Ovaries stop working. The access to these kind of data basically allow us to read the dna of over 200,000 women who are menopausal. The digital platform providing a safe space for women. Communia is a first of its Kind Social Network that builds for social health. So you can connect with yourself as much as you connect with others. And the ai generated couture collection. It was something that i wanted to wear in the metaverse, but it was also something i wanted to wear in real life. No longer taboo, the menopause has finally become a hot topic, with what many women can go through hopefully becoming better understood. So ive had a bit of a rubbish day today with feeling quite anxious. I had quite a bad nights sleep last night. Hey, so im just between cases today at work. Ijust had a quite embarrassing hot flush. Im struggling with the light. Im struggling to see. So, its 6am on Sunday Morning and im wide awake. Ive been perimenopausal for the last. Seven or so years. Definitely one of the most challenging symptoms ive found over the last few years has been the brain fog. Im trying not to be too, erm, too upset about it. Maybe, though, the way that womens Reproductive Health plays out doesnt need to be inevitable. Ive been to meet some scientists who are working on the idea of Delaying Menopause. At the Buck Institute for aging in california, neuroscientist Jennifer Garrison studies the connection between the brain and the ovaries. Menopause is basically what happens when a womans ovaries stop working. Essentially, it leads to a whole host of really Dramatic Health consequences. So ovaries are producing not just eggs for, for making babies, but also a whole host of really important hormones that are absolutely essential for overall health. When those beneficial hormones go away, what happens is a womans risk of osteoporosis, heart disease, stroke, cognitive decline, all sorts of things arthritis, depression all of those risks go way up. If we dont address age at menopause or reproductive span in women, then, essentially, were going to be making Gender Inequality worse and not better. And thats because female humans born today can expect to live on average about 100 years. And so what that means in practice is that, soon, women are going to be living more of their lives after menopause than before. Well, i can see the problem, but can menopause be delayed . We hope so. There are very few Animal Species that actually go through menopause. So, what that means to me as a scientist is that its probably not a biological imperative. Theres no benefit to it that i can see. Combine the latest Scientific Understanding of menopause and the often symptomatic years running up to it, the perimenopause, with big data and things get really interesting. At cambridge biomedical centre, genomicist Stasa Stankovic is trying to develop reliable menopause prediction tests. The access to these kind of data basically allow us to read the dna of over 200,000 women who are menopausal. We can basically analyse and understand what are the differences in their dna that actually determine at what age they will become menopausal . Some of the scientists ive spoken to have been focused more on health equality. It seems, for you, this is also about fertility. We actually capture both sides. It is really necessary for the tests in the clinic to have long term predictive potential. And, at the moment, theyjust tell you whether you are menopausal or not. Exactly, but once you detect the problem of infertility, youre usually too late to do anything about it, such as go through ivf or cryopreservation. What our tests might do is the long term predictive capability, which means that you will be able to plan your family and fertilityjourney extremely early on so that you dont end up in the situation of unexpected infertility where you dont have a solution how to battle it. How close are we to tests that can do that reliably being available for anyone to use . We are at about 60 reliability, which means we lack around 20 more to enter the clinical practice. Experts cant agree on exactly how much genetics impact the exact time of menopause. Stasa estimates it to be around 60 , the rest being down to lifestyle or health, stress or medical issues. But, particularly for those who do face it early, these tests could give some clarity. When i found out i was going through an early menopause, i think i was quite taken aback. Id been on the Oral Contraceptive Pill for quite a number of years, and i recently had a relationship break down, so i came off that, and it was whilst id come off the pill that i started getting some hot flush symptoms, and i hadnt really thought much of it at the time. But after it was happening every day, i went to the doctor to get some blood tests, and everything kind of started to unravel slowly from there, really. And it wasnt until i went through several diagnostic tests that i actually found that it was too late and id gone through the menopause and i wasnt then able to have children and i was infertile. So that was quite a lot to take on at the age of 31. Unless, of course, you could then take a drug to delay it. The imperative for someone like siobhan may be greater but research into developing therapeutics to do so is aimed at all women. Back in cambridge, scientists are replicating in mice the signs that have been identified in human dna. So, to test the genes that we find in humans, we have to work with lab scientists. So you can see here gerry working on some mouse cells, validating our targets that we discovered in humans. 0k. So what we can do with this is, first, find out what, what the reason is, or what the function of that protein is, so that then we can hopefully try to target that as a drug therapy. So, so far what weve done very well is categorise the kinds of variations that you find in large data into different groups. We know that some affect how many eggs that a woman is born with. And we know that some affect the survival of the eggs into adult life. And so thats already a big step forward in trying to understand mechanistically the different causes of infertility. There are already start ups working in this space. New york based Oviva Therapeutics is currently trialling its Menopause Delay Drug in animals, this being an engineered form of the anti mullerian hormone, which plays a crucial role in regulating reproductive potential. What oviva is developing is a therapeutic that essentially can be used to extend the ovarian reserve or the number of eggs that we have at any given point in time, and using this as a means to extend ovarian function. Now, whats interesting about this is, mechanistically, this is something you could take at any given point in your life, and it would essentially be working as an anti ageing contraceptive. And this therapeutic is something that you could start taking once youre in your 40s. Whether youre finished having your family, or perhaps you dont want children, it would be easily used at a later date, closer to when you might enter menopause, as a means to really stave that off. Health risks vary pre and post menopause. Exposing the body to hormones for longer can be associated with a higher risk of breast, ovarian or endometrial cancers. Whether this method of delay might impact that cancer risk in humans is unclear, though, so far, theres no evidence of this in animal studies. The likelihood of toxicity is quite low, but theres a lot that we need to better understand about the consequences of having that as a therapeutic, but then also of extending the function of the ovaries for longer. So i think ideally wed be able to take this therapeutic for a number of years, essentially for as long as we would want to forestall menopause. But have there been moody mice . The question of whether mood will be impacted is an interesting one, and i think we know that this is acting very early in the cycle to basically pause the eggs and follicles from entering that maturation pathway. And, in doing so, youre actually creating a little light suppression on the cycle of oestrogen in particular. Progesterone, i dont think weve seen any direct impact on. But i think the critical thing here is we just need more data. Whilst initial signs are promising, daisy� s questions over extending womens hormonal lives are echoed by other experts. Before moving into health tech, dr Stephanie Kuku was a gynaecologist also researching womens cancers. What do you think of the concept of creating therapeutics to delay menopause . Delaying menopause might mean that you are exposing the body to hormones for longer than we are naturally used to, so perhaps we need to think about what the side effects of that could be. The trouble is that we need really long periods of testing to really see these side effects. So, whilst initial, preclinical studies might show that delaying the menopause is safe, i think long term clinical studies in humans will be really important to guarantee the safety and efficacy of therapeutics to delay the menopause. If we had better treatments and more access to hrt, because hrt does work, then perhaps it wouldnt be such a topic of conversation that menopause should be delayed rather than just managed better. I definitely think if there was something along those lines then that would be really encouraging because it could. Yeah, it could really, really change some peoples lives. And i think, mainly for me, its been the Fertility Side thats had such a big impact because thats something thats now been taken away. So i think if i couldve maybe had a bit more time with that, id, yeah, it would definitely be interesting. Its hard to look back and see, but i think its very exciting that these things are possibly out there. And there is something else. Theres been a big problem with underfunding in Womens Health. Do you think that Menopause Delay is actually the right place to be investing money . So we have to think about Delaying Menopause in the context of prioritising Womens Health needs. What is Mission Critical is. Investing in trials to find Better Therapeutics for the very deadly Ovarian Cancer that has sort of limited treatment options, the right way to invest . Or should we be really thinking about Delaying Menopause in the context of who it would be most beneficial to delay menopause for . Clearly, womens experiences vary hugely. And this is controversial. But as we start to recognise the Impact Menopause has on countless Womens Health and wellbeing, the case for better or different safe treatments strengthens. Hello, it is shown with this weeks techniques. Amazon have announced the chatbot powered by artificial intelligence. Q is said to help businesses do things like summarise businesses and group chats. Amazon also that it will protect company from copyright issues around the use of its robot. Google drive users have reacted angrily to a glitch leaving some unable to access files from the last six months. Google said it was investigating the issue and it is not known how many are affected. Google drive has more than 3 billion users worldwide. Puma has successfully tested biodegradable shoes. They are a redesign of the iconic puma suede trainers. The experiment allowed 500 wearers to test trainers out the six months before returning to undergo biodegradation. We have to consider all aspects of sustainability in having a product that biodegradable be part of our future. A swedish Start Up Have created the world does make biggest tidal energy kite which is to be installed off the coast of the faro islands. Dragon 12 has a wingspan of 12 metres with the ability to power 1,000 homes. The kite swims under water against the current and generate electricity. Next, we hearfrom olivia deramus, the founder of a new Online Platform called communia. Its designed as a safe online space for women, and was set up in light of olivias own experience of assault. Laura jones has been speaking to her and a warning that this report does contain references to sexual assault. I was sexually assaulted and my story doesnt end there. I was actually sued by the perpetrator and so i learned what it was like not to be able to have a voice. Olivia was locked in a legal battle for years, during which she was unable to speak out. I was 19. There were a lot of parties happening. I actually felt really scared at this party and thought that this person was safe to leave with. After reporting the assault, their university ruled in olivias favour, but the ordeal didnt stop there, with the perpetrator pushing for a review and then suing for defamation. Abusers, especially wealthy abusers, use the grey area in the law to try to silence their victims. The thing i kept telling my mum was. If people knew what was happening. They wouldnt be ok with it. And. If i could just talk to someone who got it, who had been through something similar, that. It would feel more bearable. After the lawsuit came to a close, olivia wanted to create the safe space she felt she had desperately needed. She decided to found communia, a social media app aimed at women and nonbinary people. Communia is the first of its kind, a Social Network that builds for social health, so you can connect with yourself as much as you connect with others, through a unique digital journalling format. You can find community support, things like mood tracking, goal setting and guided journals. And then, as well as that, we do have a more twitter esque feed. And theres also an anonymous feature. There will always be things that you find difficult to say with your identity attached, whether youre being sued or not. For some, online visibility can come with a risk. According to refuge, a third of women in the uk have experienced online abuse. Suswati basu, a podcaster and formerjournalist based in london, responded to a post on x, formerly known as twitter, about asylum seekers, with her thoughts on how theyre treated in the uk. Ijust got flooded. Flooded with just homophobic, sexist, racist comments. Itjust puts you in a really vulnerable position because theres no content moderation any more. If you report accounts, it doesnt really do anything. I felt annoyed with the tech companies. Theyjust kept saying, block. Just use the block button. Its your friend. Its unacceptable and there just needs to be way more responsibility for the tech companies. Theyre not pulling their weight. X declined to comment. To tackle problems like trolling, Communia Verifies all members by email and if they want to talk about certain topics, like sex or the me too movement, they have to be verified using a photo id. When i told people in the industry that we were requiring id verification, they thought i was out of my mind. But our Conversion Rates hover around 75 and that is astronomically higher than industry average. The other thing that we do differently is that we will always have a Human Element of our moderation, even as we scale. Weve seen Big Tech Companies create incredible harm in societal conflicts through not investing in real people to moderate. And how concerned are you that the Human Content Moderators are going to be able to keep up with the kind of growth that youre hoping for . Youd be surprised by how scalable Human Moderators are, and i would invest in them over maybe some Surface Level accoutrements that you really dont need. For one communia user, these safety features were a big draw. Lucy not her real name was trying to recover from an Eating Disorder and used tumblr to find support. Id befriended someone who, on the surface, seemed to be another minor who was also suffering with anorexia and wed sort of decided to be accountability partners. He had started asking for photographs to, like, check that im not, you know, slipping back into my old habits. The messages were getting to be things that were making me more and more uncomfortable, and when id realised he was, essentially, sort of fetishizing the disorder, id stopped interacting and he proceeded to send several half nude photographs. The fact that it was clearly a man was quite startling. At the time, when i reported it, it was not deemed harassment. I felt really violated by it. It just didnt feel safe. Tumblr declined to comment. Lucys experience on other more mainstream platforms wasnt much better. No matter where you go, if you admit youre a woman, its like the environmentjust becomes sexualised automatically and that was quite distressing. Which is why a platform like communia was so appealing. The positive space for women is really important. With more than 100,000 downloads, olivia now hopes to scale the communia app to become more profitable via subscriptions. A key challenge will be not compromising on the safe space she sought to provide. Even though he sued me for millions, i didnt pay a penny. There was a moment where i had a choice to make. I could have attempted to get personal justice for myself, or i could have started communia with the funds that i had left for that legal battle. I will be damned if i dont force something positive to come out of that experience. And if i can support other women in whatever it is that theyre going through, then thats enough justice for me. And if youve been affected by issues raised in this film, details of support are available at. Ope m is an american artist and designer. She won this years Ai Fashion Week competition by Clothing Retailer revolve. This is ope� s story. My name is ope and i am a fashion futurist. It was something that i was always into. The first thing that i did with a pencil was draw some clothing. Thats my first memory. It was hard for my father to accept me as an artist because it was just not what he wanted me to do. He wanted me to be a doctor. I always wanted to be a designer, a fashion designer. Once i left school, after my father passed away, i started to manage stores. And then years later, i went and became a fashion stylist. I was always looking for subjects. I started to dabble into photography, creative direction, painting, and i was incorporating some of my paintings into all of the artwork that i was creating. So i was doing a lot. Ijust started to experiment more with digital Fashion Avatars and metaverse technology. If metaverse is gamification of life, then the nft gets you into the game. It is the game token. At that time it was novel, it was new, and so i created my first nft artwork for an art gallery inside the metaverse. Its a long process, but the short form is that i go into a programme called Gravity Sketch and i create my artwork in Gravity Sketch in 3d form, and then i take my 3d render and i put that into another application that renders it into voxels, that voxelizes it, makes it into like box like figures. I started to create for a competition called Ai Fashion Week. It included runway, it included front row, it included street style. In order to create a sketch, i have to use language to communicate to the ai what it is i want to see, and the ai will generate that item for me. So i did this repetitively to create the collection that is now seen. At that time, it was a 50 piece collection. By the time it got to revolve, it had to be edited because it was a more, you know, fantastical design. The clothes that im creating do feel a bit more powerful. I do come from wanting to see more romantic styles, but something that is also very fashion forward. Its like romance with a hard edge. And so i went through a lot of iterations with revolve to create what became a 12 piece capsule collection. It was something that i wanted to wear in the metaverse, but it was also something i wanted to wear in real life. Its so exciting that these pieces have been able to go from al sketches to actual physical, tangible pieces that i could see from the design to the fit model has been incredible because i did not imagine that that was going to be our end result. So im looking forward to all of the things that we can do, translating ai fashion into actual physical product. And thats it for this women in tech special. Thank you for watching. We shall be back next week. Bye bye. Hello. Thanks forjoining me. Lets see what the weathers up to for the best of today and, indeed, the next few days. Heres the summary for this evening. For most of us, dry and chilly and with clear skies this evening and overnight. Another frost on the way. Now, in the next few days, its actually going to turn a little less chilly. Well see these mild South Westerly is developing. Thats from around midweek onwards. The forecast, then, starting with a satellite picture. You can see how big the gaps in the clouds have been. All of that bright and we got sunny weather today. The Evening Temperatures will already be pretty low. In fact, by the time we get to around 6pm, only 4 degrees from birmingham, 5 degrees from glasgow. Generally dry, just a few showers scattered here and there. The forecast, then, for tonight. A lot of clear, dry weather. Just a few showers in the western isles. Maybe one or two out towards the west. There is a Weather Front approaching and rain for tomorrow are scared of it, before it arrives, its a frosty morning and in fact temperatures around freezing in aberdeen and on the south coast of england. Plymouth around three celsius above freezing. Weather front approaching south Western Parts of the uk so that introduces thicker cloud and outbreaks of rain i think later on in the morning. So ahead of it, a lot of bright, if not sunny weather on the net Weather Front sweeps into the south west, into wales, eventually to ireland come into Northern Ireland but notice any eastern and Northern Areas especially here in scotland should have a sunny day. The temperature is about the same, eight in aberdeen, ten in hull, 12 in london, and without strengthening wind there in cornwall and devon. Tuesday, the Weather Front moves across the uk and will fizzle out. Some light rain around in Eastern Counties and closer to the north sea coast, but out towards the west its generally dry and bright on tuesday. Again, not a huge amount of change in temperature between 9 12 celsius. Youll see that slightly warmer air sweeping across the bulk of the uk. Temperatures will be just about double figures but it will not be a huge change in the weather a little drier as we go through the course of the week. Live from london, this is bbc news. A hold up in the gaza peace talks, israel is reported not to be sending a delegation to cairo. Uk chancellorjeremy hunt has said he wants to find a way to bring down the tax burden, ahead of the Spring Budget this week. Parliament in pakistan has elected Shehbaz Sharif as Prime Minister for a second term. And its a record breaking night at the brit awards, as raye picks up six prizes hello. Our Breaking News this hour, there are reports of a hold up in negotiations for a temporary ceasefire in gaza. Israel is reported not to be sending a delegation to talks taking place in cairo. Thats despite us officials saying a Ceasefire Deal was already on the table and israel had approved it. The Sticking Point appears to be hamas not supplying a list of the hostages who would be released. Washington had been hoping for a deal by monday, taking effect before ramadan in a weeks time. Live now to our correspondent wyre davies injerusalem. Wyre, some doubt over whether an israeli delegation will attend these talks . I think those earlier rumours from washington had sent pulses racing amongst some people hoping that there may be an imminent