Introduction: Despite the health benefits of breastfeeding, Saudi women do not exclusively breastfeed their babies. The purpose of this article was to synthesize Saudi women’s breastfeeding knowledge, attitude, and practices and identify the factors that women reported for their breastfeeding cessation. Methodology: A systematic review and meta-analysis of randomized clinical trials and cross-sectional studies was undertaken. Results: Saudi women reported poor knowledge in managing breastfeeding challenges and had a positive attitude toward formula feeding. Giving premade formula and sugar water was a common practice. The breastfeeding initiation rate (31.5%, 95% confidence interval [CI]: [22%, 41.8%]) and exclusive breastfeeding at 6 months were low (15.15, 95% CI: [8%, 24%]). Perceived low milk supply, returning to work, and using contraception were the main reasons for early breastfeeding cessation. Discussion: The integration of Islamic, political, and economic cultures in Saudi Arabia can influence women’s breastfeeding practices. There is a need for culturally appropriate breastfeeding educational programs for Saudi women.