Is now risen to 15 percent its much even the higher than that amongst the youth there is a huge amount of protests swirling about the fact that the moxy might have come and stayed in tunisia but the economy is not responding and theres a great deal of pressure on the government to do something about that so theyre hoping for a smooth transition but well have to hold our breath and wait and see if they get it. Algerias the interim leader on the other ben follow has set up a 6 member panel to oversee a National Dialogue its aimed at organizing the countrys president ial election protesters say they want to complete all of the hold the ruling elite held to account for corruption moments of demonstrations led to president. Nation in april. Now u. S. Senators have backed legislation that would block some sales to solve the arabiya the Foreign Relations committee voted 13 to 9 with 3 republicans joining democrats and backing the measure many voiced concern the weapons could be used in the ongoing war and in the legislation which is expected to be opposed by President Trump would also impose sanctions on the family still ahead on the bulletin of what happens when the party stops Puerto Ricans issue a warning to the next potential governor. And an. Amateur is right in the roads of the Tour De France and a bed for equality. Hello lots of sunshine across the middle east as per usual little bit of cloud over towards the side of the region so into pakistan as the monsoon rains try to push their way into pakistan we have got some showers coming in here as we go on through the next couple days but across much of the as you can see its largely dry and settle out media could see some showers as much as catch ya anywhere between the black sea and the caspian sea but elsewhere across the middle east is dry hot and sunny 30 celsius and by route 44 celsius in fact that has been but still plenty hot enough and plenty hot enough to across the Arabian Peninsula of around 41 still a little on the humid side the winds coming in from the gulf picking up some of that moisture just pushing its way to set. 4 parts of saudi arabia could get one or 2 shells want to tear down pours into western parts of yemen over the next day or 2 theyre pushing their way across into the southern end of the red sea we get there is some right into south africa too much of thats on the cards as we go over the next couple days in fact across much of Southern Africa its pretty much blue skies all the way will see temperatures getting up to 1718 celsius for johannesburg and for cape town a high of 23 in harare and at 22 for the soka. The diagnosis he has been sick for 6 months now the challenge ahead one of these 96 could be the new cure of a new. Disability aljazeera examines. So this is the. Yes its basically where. We visited. Iraq. Its good to have you with us on aljazeera these are our top stories north korea says its latest missile test was a warning for south korea that made the announcement shortly before new photos reveal the north korean a can economy has suffered its worst year and more than 2 decades. Libyas navy says at least 115 people are missing and feared dead after 2 my friend capsized off the coast of libya but the Un Refugee Agency says the number could be as high as 150 people and the head of parliament has been sworn in as and when president after the death of 92 year old the said. The country untold president ial elections are held more than 3 months now theyre refusing to renegotiate the bricks that with the troll agreement with the u. K. s new Prime Minister e. U. Commission president told bars johnson of the following that the existing deal is the best and only one possible johnson insists he can get a new deal by the end of october Charlie Angela reports from london. Inside 10 downing street a rousing welcome from a loyal team Prime MinisterBoris Johnsons new cabinet dominated by bricks it hard liners at the 1st pep talk and we have a momentous task. In our countrys history we are committed. To leaving the european. Really dont know if theyre not oh do i apologize for interrupting the premise of this far too much noise in this training but in parliament a very different johnson had promised to unite the conservative party but his rethink decision to sack sideline 17 senior ministers may have done the opposite. His 1st statement was one of optimism channeling his hero Winston Churchill promising a golden era for britain and then a message to the European Union asking him to rethink the current deal no country that values its independence and indeed it so for suspect could agree to a treaty would sign away our economic independence and selfgovernment as this back story does a time limit is not enough if an agreement is to be reached it must be clearly understood that the way to the deal goes by way of the abolition of the backstop a request politely rejected by brussels with the e. U. s chief negotiator saying that eliminating the backstop is unacceptable and not within the mandate of the European Council a message reiterated by the Outgoing European Commission president in a phone call with Boris Johnson with saying that the e. U. s position on the Withdrawal Agreement is the best and only way possible this is the last day parliament will sit before breaking for the summer but the challenges facing the new Prime Minister are immense negotiate a new bracelet deal in just 98. 00 days a deal the e. U. Says cannot be renegotiated and fix a multitude of problems facing britain and Health Care Education and security all with a parliamentary majority of just 3 many say the country could be heading for a general election i think that Boris Johnson if he sees that hes going to lose a vote of say no confidence in the house of commons i think he would rather call the election than wait for his government to fall and the election to follow he would rather stay on the front foot so i think the whole of britain ought to be on the alert for an early snap general election called perhaps right at the beginning of september that might happen. Is that this get to these this is a Prime Minister with a deadline like no. Facing unprecedented opposition hoping his optimism is infectious charly angela aljazeera london. Now thousands of people in malawi a continue to protest against the results of maize general election the military fired tear gas and block demonstrators from march into president. Residence they want to present a petition challenging the results which they say a rent a court case on the results is expected to begin soon. Now celebrations are continuing in puerto rico following the resignation of the islands governor ricardo announced her leave office on wednesday following 2 weeks of protests which was sparked by the release of offensive messages between you and his aides adding to the foster ation of a government corruption and a gallic of reports from. Dancing in the streets of san juan celebrating whats being called a peoples revolution demonstrators have for days demanded governor ricardo rajjo step down after Text Messages revealed a leader who spoke poorly of his own people and used sexist and homophobic language to young Puerto Ricans who spearheaded the marches its in the bed to victory i mean i bet you were here when you saw a 1000000 people on the street and thats amazing that thats. So. Beautiful man its no words for that i have 22 sons one is 10 and the other is 8 so i do this for them and for my future maybe grandsons you know and for the people of puerto rico in one of their we just simply the no one there because they were facts that he was in a good governor so we just had to do something the demonstrations began almost 2 weeks ago these were some of the biggest marches in the islands history from a population tired of accusations of corruption and mismanagement later on wednesday night governor ricardo rajjo a. He would step down on august the 2nd. The streets of san juan erupted in celebrations that continued for hours puerto ricos secretary of justice one device is likely to replace ross aoe but shes in a popular choice among those who took to the streets organizers say they will watch closely what happens next with their demands for the future of puerto rico the simple so we just want good leaders true leaders people that are just looking for the you know well being of the people thats all we need really is not its not really that difficult protesters say they will continue to demonstrate if this u. S. Territory fails to pick a governor they like the next few days or a c. E. O. Successor will be announced but this political crisis may be far from over for many people here this feels like a brand new day the one thats been used with hope and concern remember the next governor will inherit 74000000000 dollars worth of debt on an island still recovering from 2 major hurricanes committed in anything else the future leadership of this country will have to wind its Peoples Trust and that may be the biggest challenge and again across the syria san juan puerto rico. Now the u. S. Government will resume execution prison is off to a 16 year pause all executions since 2003 have been carried out as a state level they were 25 last year attorney general william bar has now made the decision to reinstate Capital Punishment at the federal level President Trump has long called for more executions. A hate twains has sent temperatures soaring across europe breaking records and france britain belgium and the netherlands a new high in germany for the shutdown of a Nuclear Reactor the water became too hot but the increasingly common heat waves are also serving as a reminder of the impact of Climate Change now the baba reports from london. Enjoying the heat in. The water fountains by the eiffel tower are a popular place for those trying to stay cool. As a red alert was issued for northern france in the capital reached an all Time National record of 41. 00 celsius well french media reports suggest 5 deaths might to be linked to the current heat wave. On wednesday belgium germany and the netherlands all recorded their highest ever temperatures and they did it again on thursday topping 40 degrees celsius. While some in the belgian capital brussels are making the most of it its led to a socalled code red being issued for the 1st time. Since 1933 so nearly 200 years we never experience this kind of temperatures over in britain as temperatures soared activists in london staged a small protest outside bass building housing Media Outlets demanding they concentrate less on images of fun in the sun and more in explaining the extreme weather. We cant talk about stay on record with headlines like war scorcher without looking into why is it the high stakes and what does that mean for humanity whats that mean in the next 102030 years. There were to eat for food for particularly for people in developing countries who this is affecting right now but aljazeera had no difficulty finding people who are concerned about whats driving the increasingly common heat waves people start realizing that things are changing and quite quickly in climate and so yes it is the moment to just to change something. Before its too late this is something that makes our planet less. Comfortable to live on say we have to think about how to stop it so that also our children can still survive on this planet most people here in Britain Welcome a bit of sunshine but for when the humidity and on a day like this the priority for lots of people is actually staying in the shade more broadly more and more starting to draw the line between europe 6 streams summers and the climate crisis. The u. K. Governments Advisory Committee on Climate Change has warned the country is not prepared for the extremes that Global Warming is expected to bring here the current heat wave which prompted Health Warnings brought trains to a standstill in some parts. And in Southern Europe this was greece on wednesday a series of wildfires are a reminder of conditions that many are calling the new normal. But while those conditions have their upsides they bring their own dangers the dean barber aljazeera. Less than is cutting more than 12000. 00 jobs around the world in the next 4 years the crisis of the japanese car giant has deepened since their rest of former chairman carlos gone with a curious to financial misconduct the company blamed sluggish sales and rising costs now a group of female amateurs are riding every stage of the Tour De France ahead of the male pros theyre trying to push for a womans version of cyclings biggest race the Tour De France organizers say it isnt possible and now has more from the french alps. The spectacular peaks of the french alps still dotted with patches of snow despite the summer heat there is no our mountain passes more than 2300 meters high for these riders its a tantalizing test of strength and part of a campaign for womens Tour De France the worlds most famous bike race is exclusively for men we want a womens race equal to the mens because the tour of course is monuments its the race for the best way to encourage young women to cycle is with Media Coverage of a big womens race 5 years ago this group of women set out to raise awareness about the inequalities in professional cycling each july they ride all 21. 00 stages of the tour its a challenging route of nearly 3500 kilometers but they do so in conditions far less comfortable than the mens with traffic a modest support team. No prize money or fanfare. This year these International Riders have joined them where every day girls have got full time jobs and if we can do it anybody can do it weve got a lot fatigue in the legs as well i mean nations all over the place as well because its quite draining mentally as well as physically because we dont have the support that the professionals have in the 1980 s. The organizers of the Tour De France experimented with the womens race but they said that it failed to attract enough public and Media Attention but times have changed womens sport is popular and now the organizers are saying that they are considering an equivalent womens race. The a. S. O. Company that runs the tour has yet to provide details of a future race but its expected to be longer than they were one day womens event these tour enthusiastic say it would be a welcome addition to the cycling calendar. Womans World Cup Team had lots of coverage so why not a womens Tour De France at the end of the 18th stage the galley be a pass is a grueling climb but the prospect of a womens tour makes the effort worthwhile to dont want to just move euphoric at the idea that the organizers of the tour think it is possible to create a big stage race in france for women riders on the really deserve it. Reaching the top is overwhelming for some but the sense of achievement is clear and with only days until the end of the 3 week challenge these women are riding high Natasha Butler the galbi pass the alps france. Hello again elizabeth problem and of the headlines on aljazeera north korea says its latest missile tests were a warning to south korea thats demanding seoul and a joint military drills with the United States but the u. S. Secretary of state says hes still open to talks on day nuclear. Zation now sanctions on north korea appear to have a devastating effect south koreas Central Bank Says the north g. D. P. Fell by 4 point one percent last year that is the worst drop in more than 2 decades in the 2nd Consecutive Year lead decline from a bright has more from solve all of this rotten anger seems to be directed at south korea and none of it directed at the us which after all is also taking part in the exercises and is supplying the f. 35 fighter jet so still very much following the line of not having any direct attacks or anger directed at the Us Administration of donald trump keeping open it seems the prospect of further dialogue the un is demanding immediate action after the worst boat capsizing in the mediterranean so far this year as many as 150. 00 refugees and migrants are known to have drowned off the libyan coast the un is calling for safe and legal votes for those searching for a better life to know if he is 1st democratically elected president of beijing or the said she has died aged 92 the head of the as parliament mohamad n. R. Sir has been sworn in as interim president he leaves the country until elections are held within 3 months the European Union says it wont renegotiate the brics that Withdrawal Agreement with the u. K. s new Prime Minister e. U. Commission president John Paul John khattala boss johnson out of the forum that the existing deal is the best and only one. Record heat wave is continuing across western europe paris recorded its highest ever temperature on thursday at 42. 6 degrees celsius and National Records were also set to the netherlands belgium and germany those are the headlines on aljazeera the cure revisited is up next. The Palestine National locust was 1st founded in the 1930 s. But has had to be revived in 20 chan all was very important for me to sing in palestine now musicians from all over the world come together to perform in the occupied territories so you can philistine its like every palestinian living in the aspirant felt it was the 1st time they perform using their identity aljazeera world hears music as a force for unity the diaspora orchestra. To pass think of this story as its. Wow. So this is the explosive yes its basically a wearable robot. Research and development from new medicines is costly and time consuming and almost always profit driven so where disease affects only the poor but market is neglected meaning no new medicines. As one such neglected tropical disease its the worlds 2nd Largest Party to kill off to malaria killing 40000 people every year but has had no new drugs developed for decades im dr dobson when i mean ethiopia to explore how big pharma are being mobilized in an unprecedented Global Initiative to find and fast track a cure for. Colors are also known as visceral leishmaniasis is a parasitic disease transmitted through the bite of infected sounds like. When they feed on humans parasites infect the body and internalized by microfiche is immune cells designed to protect us from infections. Here the parasites multiply and destroy the last infecting other 5 pacific cells the parasites that move through the lymphatic and vascular systems infiltrating the bone marrow liver and spleen. Symptoms include fever weight loss enlargement of the liver and spleen anemia and the weakened immune system. With the disease affects millions across 98. 00 countries. Just north of the equator here due to the hot climate and i grew cultural lifestyle colors are as endemic. Ethiopia learned has more than 4 and a half 1000 patients every year many of them male migrant farm workers working long hours in the field. With them its a 3 to 4 hour drive to the nearest Treatment Center but for those are unable to pay for transport its a long walk. Fortunately their destination is the center for the treatment of color. For the last 10 years. Gondar University Hospital has been conducting successful Clinical Trials involving the combination of 2 all drugs sodium stupid lucan 8 or s. S. G. And paramour mice. In 2010 the World Health Organization officially adopted this combination as the new 1st line therapy for callas are in east africa its the 1st movement in half a century and dr aramis deros has been leading the way. Our previous regimen was so damn stupid to commit for such a few days with a combination we were able to shorten that regimen to 17 days thats good yes indeed and if you can see was more cement factor sent so you managed to cure 95 percent of patients where is the new combination is that much better than before well in terms of if it is more or less similar. But in terms of. Hospital hospitals base it tends or spittle base to 17 thats the biggest tournament. Just 2 drug combination therapy is safe and has almost half the hospital stay of the earlier treatment. Thats a crucial reduction for both patients eager to return to work and the Health Sector struggling to accommodate everyone currently all 26 beds here are full. Plate everything is love it must be nice to meet if youre welcomed this is it yes Leishmaniasis Research treatment. Because. After the heavy demands of this years high season the hospital has run out of power m m i said and despite the new w. H. O. Guidelines its forced to return to the full 30 day regimen of painful and toxic s. S. G. Injections. So this is one of old works. Hello it feels very hard how long have you had fever. Because you know better but. Gosh he has been sick for around 6 months now right. There mary you still have pain in your stomach that i think you were asked. Who was 1st suspected of having malaria due to the similarity in early symptoms. But after not responding to treatment he was referred to another clinic which finally diagnosed colors are. Now 6 months after he 1st fell ill hes in good hands but if it was left any longer he might not have been so lucky. Patients who are in very remote places not able to find out. And subsequently when the really weak and i got to. Go. And now that youre here in hospital. Not working how does that affect your earnings schema surely can change us that its also that there are tons. Of mistakes and being in. Debt us a nation can lead to. Them but who is likely to normalise within a week still like all colors our patience due to the dangers of s. S. G. Hill require around the clock monitoring and toxicity testing for the entire 31. 00 days of treatment. The new combination therapy is an improvement but until these toxic drugs are replaced entirely by new safer and more if acacias ones its still not good enough. As a neglected tropical disease. Is desperately in need of a new research and development boost. A few 1000 miles away help is at hand through a new Global Initiative. Were here in geneva not far in fighting the un and the World Health Organization but over here were going to meet the n. T. I. The drugs the neglected diseases initiative. The n. D. I. Are the Nonprofit Organization behind the s. S. G. P. M. Development. Founded in 2003 with the help of medicines of frontier nobel prize money theyve been rallying commercial pharmaceutical companies around the world to share their resources. Already gained access to a limited selection of big pharma drug libraries and now have a portfolio of 15 promising new drugs in various stages of trial for several neglected diseases but now its a particularly important time for them to see Charlie Mowbray head of Drug Discovery is the architect of the all new n t d Drug Discovery booster a project is. And to access and speed up new therapies for color as well its a great time to visit is an email on just about the center for the worlds leading pharmaceutical companies ok so after america. Ace high qaeda quickly ok you can see here theres a chemical structure or some information here of different ways of depicting the structure or its activity against the parasite also it was the kilty crusie that causation across so this compound will kill the parasites that cause disease and leishmaniasis really we would have screened 100000. 00 compounds maybe to find this one they really precious the parasites are really difficult to kill the properties of this is still quite a long way away from what we need for something or long from really become an oral meds from swallow and itll kill the parasite so we would normally have to start making compounds my hand one at a time really slow really expensive but the companies that have been working in Drug Discovery for 50 or a 100 years already have big collections hundreds of thousands or even millions of compounds and theyre going to have some good look a bit like this one this is Drug Discovery. D. N. D. I is essentially on the hunt for a look alike to this compound one that may have even Better Properties for the purposes of a new drug for colors are. But they cant do it alone thats where the booster comes in participating Pharmaceutical Company has effectively opened their entire back catalogue and whats more theyll lead the search themselves if you persuaded these companies and its in their interest to do. What i think was many many motivations but one of the things i like im a scientist i used to work for francois Pharmaceutical Company the people on the other side of this project and no different from me theyre really excited about working on a disease like this because we can all see the appalling need here most people want to help and i hope some other companies are going to join this project quite soon so we really want this to be a global console to really name and shame the ones i have inside. Where were working hard with some other companies. It takes a long time in discussions like this we hope some of the companies will join us are great so youre going to click send well im just about to do that so so yeah we can send it. And that will be off the off. In the u. K. In japan at the end but drugs will be made available at no cost or low cost to the patients that need them so an exciting time fingers crossed. For pharmaceutical giants have so far signed the booster contract which means d n d i now gain unlimited access to millions of compounds one of the companies astra zeneca is in the u. K. The other 3 are in japan shinobi. And days i have received charlies emails with the seat. Were looking for the man received the email from d. M. G. I i believe is in here and so she is high or low its nice to meet she let me see how they have that so you look at structure of molecules on computer models as well as in real life clinically sure yes you can use only what you do for us thats a fluke out there and i think its this going vessels really 3 dimensional our structures are no. Biggie for us all these compounds that see the compounds and imagine this is the seed that came from the n. D. I. The n. D. I. Seed is 17 parts carbon 4 parts nitrogen 15 parts hydrogen and one part chlorine connected into this unique shape. This combination and shape closely fits and binds to a vulnerable spot on the leash mania parasites interfering with their mechanics by so far unknown mechanism but the fit could be better its like fitting a key to a lock by intelligent trial and error 1. 0 is a shop for food fight this is simple ok this is not a sin but you dont have to be a chemist to say that this doesnt look like that so i would search similar compound based on chemical for updates on sudan and i took a chance