A guided capability and labeling it to avoid interception now if this is true then it means that north korea while they have certainly stopped Nuclear Testing on the launch of bigger Intercontinental Ballistic Missiles are still developing their Weapons Systems its a message that has been driven home with the release of photographs earlier this week of kim jong un the north Korean Leader visiting a submarine in a shipyard now its not known whether this is a new submarine under construction of the North Koreans claim or simply an older type of sub that is being refitted but the consensus among analysts is that it is a submarine that is large enough to carry submarine launched Ballistic Missiles a technology that North Koreans have been trying to develop over the last couple of years i think people are in south korea japan and the United States need to be more cons on the bar inspection breaking down of the new type of submarine. Test firing of short range of projectiles because if north korea acquires Nuclear Submarines they can launch nuclear pull this thing missiles then it would be a game changer thursdays Missile Launch it seems to be an expression of north korean anger at upcoming exercises between south korean and u. S. Forces in august and also showing its frustration that once again talks seem to have stalled even after the heightened hopes of the surprise meeting between donald trump and kim jong il. At the d. M. Z. Barely a few weeks ago it is the fear of talks collapsing that has led to a guarded response from south korea saying that the launch of the missiles was a threat but not necessarily a provocation japan had a firm a response saying that if this does turn out to be Ballistic Missiles even though they were short range this does violate u. N. Resolutions and could and should possibly have consequences on the weather is next but still ahead on al jazeera and now that major layoffs in the global car industry this time necessary and that sco of more than 12000 jobs a wild wired. And are there still those plumber ains impiety much of central and southern areas of china the satellite flossy as relatively care cost more eastern sections as you can see but the right is very extensive it has been the last few days and will continue to over the next couple of course seasonal southern areas you can see its a trailing all the way down across into sections of thailand and also with vietnam cambodia that falls south dakota hong kong 32. 00 is the high a warm day in shanghai at 37. 00 degrees celsius and it should be mostly dry for you further towards the west across into india now this is where of course weve seen some very impressive monsoon rains the satellite showing you some of a large bright arrows of clouds over the last several hours and the rain really is very extensive across much of the continent right there way up to the north in fact well even see some rain showers pushing across into pakistan over the next couple of days 27 degrees in poor on friday 29 in new delhi that temperature hasnt she really come down a few degrees in the last couple days because of all the rain that is very much in the forecast and. Then on saturday you can see this time which is again lower than weve seen for quite a while 24 in katmandu again those rains extends across much of nepal and then weve got a high of 29 in mumbai. The diagnosis she has been sick for around 6 months now the challenge ahead one of these 96 could be the new cool or basis of a new tool the colors are new. Disability aljazeera examines pioneering the treatment so this is the next here its basically a wearable robot. Revisited now does iraq. Hello again im. With a reminder of our top stories this hour the head of chinas ias parliament mahomedan austria has just been sworn in as the countrys new interim president he takes over after his predecessor 92 year old. Died on thursday. And his 1st speech to parliament as britains new Prime Minister baraks johnson the European Union to rethink its refusal to renegotiate breaks a deal he says his government will prioritize leaving without an agreement if theres no deal with the e. U. By the october 31st deadline. And north korea has conducted its fast a Ballistic Missile test since u. S. President donald trump met kim jong un nearly a month ago south korea and japan say 2 weapons were fired into the. Now libyas navy says at least 115. 00 people are still missing after a shipwreck off its coast around 140. 00 were rescued and are being returned to libya libya is a hub for migrants many of whom tried to reach europe in risky boats u. N. Agencies have repeatedly called for survivors not to be returned to libya because of the conflicts in the country while Charlie Yaxley from the United Nations Refugee Agency has reacted to the sinking saying today we have seen yet another tragedy on the mediterranean according to testimony from survivors its estimated that some 150 people have died at sea which would make this the largest shipwreck on the mediterranean in 2019 this horrific Event Highlights once again the dian need for a shift in approach to the mediterranean situation into action is needed to save lives at sea and to prevent people from getting on these boats in the fast place by offering safe legal alternatives well earlier i spoke to len a doornail whos the spokesman for the International Organization for migration and he says the latest shipwreck continues a worrying trend in the mediterranean. There would be about 4000. 00 people whove taken to see this year and have been intercepted arrested or brought back suddenly typically put into detention which we are so its really its it is a 0 sum game for the migrant to say that they think theyre going to try to get a better life they end up in the hands of a smuggler is usually quite often abused and then if it you make it out of the house it brought back and in this case not picked up a drama about 300 people left some guns in wooden boat we understand they were then put into relatives on the high seas out of which one bill says has one box its a 100 turns by the 150 people thats on land and the survivors such as they are managed to swim ashore but the numbers are particularly high dramatic we need clearly to have some stability and in libya the problem is that theres a conflict going on and my recently come upon a game there used to make money for people looking after to pay their passage quite often by being indentured servitude in effect and then theyre put in the house these are just not a happy situation the europeans turning away from it are banning boats from rescue people are certainly not the way to go. Now celebrations are continuing and push a day off to the u. S. Territories gov because they are resigned following mass protests thousands have been fed a bracing with a his resignation on the streets of the capital side while his government was facing corruption allegations and he along with some officials at the center of a text message scandal more now on wednesday wednesday nights developments from our correspondents caper let us on day. A victory for the people and this was the moment they found out after 2 weeks of street protests it was near the border east coast governor carter rocio said he would try to step down. The side of the call that is going on the goal of despite having a mandate from the people who elected me democratically today i feel that continuing in this position presents censored mountable difficulties adding heard the complaints spoken to my family thought of my children any prayers ive taken the following decision i announced to you today that ill be resigning as governor effective friday 2nd of august. Those of the street she laid it. Was. My reply was so i said ok so what are you feeling i know. This is such but richard well here goes the world were going to protest the man. Theyre calling it revolution it others might say its puerto ricos arab spring i was i was euphoric i couldnt believe it i those 1st generation do you know how cold proud you feel you know the 1st generation to get out. Were not out of the island just because we said so we went to the streets and its a power of a. Change of power that began with 2 cabinet members people arrested by the f. B. I. For alleged corruption and one was a minister of education. And was followed by the leaking of private Text Messages sent by the governor in them he insulted his own people beat bulger comments about women and appeared to joke about the Puerto Ricans killed in the hurricane area 2 years ago but this was a transition also about a people who rose up and demanded more from their leaders on an island thats a us territory this was a Resistance Movement i would say finally you know all the power energy frustration came out we had everybody with us this is what it was its and its here to stay we are demanding big changes from our government not just this resignation this is going for long its an overhaul of government and our institutions. 2 weeks ago taking to the streets these people say they reclaim their government and now they can celebrate gabriels and do ill just see that san juan puerto rico. And the sun will sack 12500 workers by 2023 they arrest a former chairman carlos go on a november has seen the automotive giant struggle to revive Growth Management says its now causing costs and june u. S. Vehicle make a ford announced its plans to x. 12000 jobs across Europe David Kiley is the editor in chief of near writes media and he says nestle is under growing pressure from corn its case and a Global Economic slowdown. They are i think suffering from the vacuum that was created by carlos goans ouster their own is a very hard driven. Powerful c. E. O. Who constantly sort of whipped the Global Operation of the sun as well as the local alliance between nissan and renault to achieve profitability results well now youve got mr 6. Head of the sun without carlos you know. The. System and he had a terrible 1st quarter. At the same time youve got auto makers like nissan for General Motors preparing for a global slowdown. In auto sales weve already seen it start to happen in europe. And we are expecting a slowdown in north america as well between 20182025. Now i hate wave has sent temperatures soaring across europe breaking records and france britain belgium and the netherlands and even forced the shutdown of a Nuclear Reactor and gemini as the water got too hot the eiffel towers fountains a become a refuge for permissions with the city recording its highest temperature on fast day 42. 4 degree fell from has issued its top heatwave the last level warning the public of potentially deadly temperatures on across the channel britains experiencing its hottest july with temperatures still rising heading for a wreck or creeping towards a fatty 9 degrees belgium has already broken its highest mach topping 40 degrees on thursday the hottest in almost 200 he is keeping records Scientists Say the never before seen temperatures may now be the new normal. During summer we have usually. Some heat waves but the exceptional fact of this year is that the temperatures have risen very high for belgium and that. We see in during the usually these last years that did the heatwave are more and more frequent. While People Living on the slopes of the most active volcano in indonesia are used to danger 275 were killed when round her up erupted 9 years ago but since then survivors of returns to their villages and farms and as florence are reports some of us have found new ways to make a living. When the weekend arrives so do the tourists hundreds of them by the bus load that day pollen to off road trucks and head off bumping along dusty trails for Close Encounter with indonesias most active volcano the alert level for mt merapi is now low its 9 years since the last major eruption. Turrets allowed to go into the danger zone as close as 4 kilometers from the crater. So. To be a cattle farmer but turned to off road driving after his neighbor persuaded him to give it a go but. We never theres been an interruption tourists are a bit weary and stay away but they come back when the government says its a volcano is dangerous of course but there are also been a fits. He sold some of his cows to buy his 1st utility. Now he has 3. This tour has become so popular that theyre now about 900 jeeps that cater to visitors the highlight is the driving through a river and fans from the 2010 eruption. Its not just nature and the spectacular views that attract the tourists this museum of sorts is a testament to the power of. A collection of Household Items destroyed in the eruption in 2010 that killed 275 people. Dunn is on his 2nd visit to merapi. Family i was very happy and excited my 1st time here but this trip i feel a bit sad thinking about the people who died but its a good tour it educates people especially for people who live in disaster prone addie yes they know how devastating such a cure insists can be. Assy knows just how deadly merapi can be. Hes the volcanos spiritual guardian a traditional role going back generations. He succeeded his father who was killed in the eruption line years ago. People still come to pay their respects to him. Though. Take grass from a rap be we take rocks and sand to build houses we need to love more rapidly its terrifying when it explodes but when it comes down we need to come back and take care of it. The people of no they live in the shadow of danger but have learned to adapt and even benefit from it Florence Louis aljazeera mount merapi indonesia. Now the french inventor known as the flying man has failed in his attempt to cross the English Channel on his jet powered fly aboard frankie the paso was rescued after falling into the sea during a refueling stop he was only allowed to refuel once on a but it is about a plan to land on the british coast near dover after a flight of 20 minutes but the former jet skiing champion says hes not giving up despite a disappointing day could you move a little move i had a tough break and im disappointed for sure but i believe youre probably was unable to fly a plane when you tried it for the 1st time in the history of aviation is made of people and its only when you get back you cant make any progress and i said it before this challenge was extremely complex. With the headlines on aljazeera the head of china sea as parliament muhammad in austria has just been sworn in as the countrys new interim president he takes over after his predecessor 92 year old said he died on thursday and austria could be in charge for up to 90 days while fresh president ial elections are organized they were meant to be held in november but now theyll be brought forward in his 1st speech to parliament as britains new Prime Minister bars johnson and the European Union to think about its refusal to renegotiate a bricks a deal he says his government will prioritize leaving without an agreement if it looks like theyll be no deal by the october 31st deadline. Our mission is to deliver british on the 31st of all turns out for the purpose of uniting and reenergizing our great you know if you can you are making this country the greatest place. On earth. North korea has conducted its fast Ballistic Missile test since u. S. President donald trump met kim jong un nearly a month ago south korea and japan say 2 weapons were fired into the sea libyas navy says at least one 115. 00 people are missing in a shipwreck off its cost around 140. 00 were rescued and are being returned to libya libya is a hub for migrants many of whom tried to reach europe in risky boats u. N. Agencies have repeatedly called for survivors not to be returned to libya because of conflicts in the country and celebrations are continuing in puerto rico a day after the u. S. Territories governor is a are resigned following mass protests thousands have been celebrating was it was resignation on the streets of the capital sounds fun his government was facing corruption allegations and he along with some top aides at the center of the text message scandal. Well those are the headlines ill be back with more news here after the cure revisited do stay with us on aljazeera. Please. Help us think of this story its its 1010 years. Wow. So this is the explosive yes its basically a wearable robot. Research and development from new medicines is costly and time consuming and almost always profit driven so where disease affects only the poor it is neglected meaning no new medicines. To tropical disease its the worlds 2nd largest processor killer off to malaria killing 40000. 00 people every year but has had no new drugs developed for decades. Im dr dobson when i mean ethiopia to explore how big pharma are being mobilized in an unprecedented Global Initiative to find and fast track a cure for. Colors are also known as visceral leishmaniasis is a parasitic disease transmitted through the bite of infected sandflies. When they feed on humans parasites infect the body and are internalized by microfiche is immune cells designed to protect us from infections. Here the parasites multiply and destroy the loss infecting other 5 pacific cells the parasites that move through the lymphatic and vascular systems infiltrating the bone marrow liver and spleen. Symptoms include fever weight loss enlargement of the liver and spleen anemia and the weakened immune system. As a disease affects millions across 98 countries. Load and rural it just north of the equator here due to the hot climate an agricultural lifestyle colors are is endemic. Ethiopia learned has more than 4 and a half 1000 patients every year many of them male migrant farm workers working long hours in the field. With them its a 3 to 4 hour drive to the nearest Treatment Center but for those are unable to pay for transport its a long walk. Fortunately their destination is the center for the treatment of color. For the last 10 years going to University Hospital has been conducting successful Clinical Trials involving the combination of 2 all drugs so damn stupid lou can 8 or s. S. G. And para myself. In 2010 the World Health Organization officially adopted this combination as the new 1st line therapy for callous in east africa its the 1st movement in half a century and dr aramis deros has been leading the way. Our previous regimen was so demonstrable to commit force that a few days with a combination of were able to shorten that regimen to 17 days is good yes indeed and if you can see was more cement factor sent so you managed to cure 95 percent of patients where is the new combination is that much better than before well in terms of if it is more or less similar. But in terms of. Hospital hospital days its shortened or spittal based to 17 thats a big achievement. Just 2 drug combination therapy is safe and has almost half the hospital stay of the earlier treatment. Thats a crucial reduction for both patients eager to return to work and the Health Sector struggling to accommodate everyone currently all 26 beds here are full. Play everything is love it must be nice to meet if you will come this is it yes Leishmaniasis Research treatments. After the heavy demands of this years high season the hospital has run out of power in my city and despite the new w. H. O. Guidelines is forced to return to the full 30 day regimen of painful and toxic s. S. G. Injections. So this is one of the worse. Hello he feels very heart fever how long have you had fever. You know. Gosh he has been sick for around 6 months now and then mary you still have pain in your stomach that i think you were asked. To was 1st suspected of having malaria due to the similarity in early symptoms. But after not responding to treatment he was referred to another clinic which finally diagnosed colors are. Now 6 months after he 1st fell ill hes in good hands but if it was left any longer he might not have been so lucky. Patients who live in a very remote place is not able to find out. And subsequently when they. Really weak and. Then they go. And now that youre here in hospital. Not working how does that affect your earnings the schema surely can change or stand on its ass and. There are tons. Of mistakes and being it. Would be mad at us and mission. Is likely to normalize within a week still like all colors our patients due to the dangers of s. S. G. Kill require around the clock monitoring and toxicity testing for the entire 31 days of treatment. The new combination therapy is an improvement but until these toxic drugs are replaced entirely by new safer and more if acacias ones its still not good enough. As a neglected tropical disease. Is desperately in need of a new research and development boost. A few 1000 miles away help is at hand through a new Global Initiative. Were here in geneva not far in fighting the un and the World Health Organization but over here were going to meet the n. T. I. The drugs the neglected diseases initiative. D. N. D. I are the Nonprofit Organization behind the s. S. G. P. M. Development. Founded in 2003 with the help of medicine so frontier nobel prize money theyve been rallying commercial pharmaceutical companies around the world to share their resources. Already gained access to a limited selection of big pharma drug libraries and now have a portfolio of 15 promising new drugs in various stages of trial for several neglected diseases but now its a particularly important time for them going to see Charlie Mowbray head of Drug Discovery is the architect of the all new n t d Drug Discovery booster a project is. And to access and speed up new therapies for color well its a great time to visit is an email on just about the center for the worlds leading pharmaceutical companies ok so actors america. Ace high to cater quickly you can see here theres a chemical structure or some information here of different ways of depicting the structure or its activity against the parasite also it happens to kill t. Crusie that causation i guess so this compound will kill the parasites that cause disease and leishmaniasis really we will have screened 100000 compounds maybe to find this one they really precious the parasites are really difficult to kill the properties of this is still quite a long way away from what we need for something or long from really become an oral meds from swallow and itll kill the parasite so we would normally have to start making compounds my hand one at a time really slow really expensive but the companies that have been working in Drug Discovery for 50 or 100 years already have big collections hundreds of thousands or even millions of compounds and theyre going to have some good look a bit like this one this is Drug Discovery. D. N. D. I is essentially on the hunt for a look alike to this compound one that may have even Better Properties for the purposes of a new drug for colors are. But they cant do it alone thats where the booster comes in participating Pharmaceutical Company has effectively opened their entire back catalogue and whats more theyll lead the search themselves have you persuaded these companies and its in their interests to do. What i think has many many motivations but one of the things i like im a scientist i used to work for fanta Pharmaceutical Company the people on the other side of this project and no different from me theyre really excited about working on a disease like this because we can all see the appalling need here most people want to help and i hope some other companies are going to join this project quite soon so we really want this to be a Global Consortium name and shame the ones i have inside here. 7 where were working hard with some other companies. It takes a long time in discussions like this we hope some of the companies will join us here and so youre going to click send well im just about to do that so that we can send it. And ill be off the wall part as in the u. K. And japan and at the end of the drugs will be made available at no cost or low cost to the patients that need them so an exciting time fingers crossed. For pharmaceutical giants have so far signed the booster contract which means d. N. D. I now gain unlimited access to millions of compounds one of the companys astra zeneca is in the u. K. The other 3 are in japan shinobi. And days i have received charlies email with the seat. Were looking for the man received the email from d. M. G. I i believe is in here and so she high or low its nice to meet she let me think theyd have that so you look at structure of molecules on computer models as well as in real life technically sure yes in your family what you do for us thats a fluke out there. If this sporting event best sleep 3 dimensional structure. This is us all these compounds that see the compounds and imagine this is the seed that came from the n. D. I. The n. D. I. Seed is 17 parts carbon 4 parts nitrogen 15 parts hydrogen and one part chlorine connected into this unique shape. This combination and shape closely fits and binds to a vulnerable spot on the leash mania parasites interfering with their mechanics by so far im known mechanism but the fit could be better just like fitting a key to a lock by intelligent trial and error 1. 0 is a shop for food fight this is simple ok this is not a sin but you dont have to be a chemist to say that this doesnt look like that so i would such a similar compound based on chemical for updates on sudan and i took jan your answer saw that soul screening is a runny oh yes a generally quick round yes they are at 94 percent and you can see 2 rings 2 rings triangles and the next one is 85 percent and so on and so forth that didnt even take 2 seconds. After a successful scan for compound
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