Aljazeera. For some trick of nature these stem cells and white swan are on. Which this whole procedure is a bad. Joke like a bank but its more sophisticated listening to what it is out by a born american like us relations. It just might at that worldwide 350000000 people are affected by genetic disorders closed by faulty d. N. A. These genetic defects can lead to a variety of conditions like Cystic Fibrosis which leads to conic and also site along the functions at the moment the system and here i am dr Elizabeth Healy in the u. K. To see how groundbreaking developments in gene therapy could one day transform the lives of People Living with genetic disorders. L. L. S. But not mary bond on air is 16 years old and was diagnosed with Cystic Fibrosis at the age of one. America tell me from your perspective what is your day like living with Cystic Fibrosis. Erin when i asked her i guess op take my interview arises off eyes. And then her sitting in my inbox tears. And i asked to you i know now your eyes are failing. And theyre nasty my physio and. I do spiral a. J. And theyre going to go out and join me in their helping me. And then often ask to do another not be lies well. There are still more process. And then i will need face oh so you have 0 now so learn. The night. When mary was 1st diagnosed doctors thought she would only live until the age of 4. I did feel i was dazed and not ready until marriage and. Im not house turned on i thought id like them on occasion then of ok. Theres never a day goes by either and taught everybody forget the whole thing you know live it up so i know its always there. Married to use me to the children to see if i purses no more can kiss our voices if i me one of them they want to pos i just want to me all on one particular thing to them. Now you see quite an isolating condition to near yet is always enough so i now was not so youre haitian now right. So i only used to send your letters to h. R. Because they couldnt me if they said they saw me fly now last night at the moment mary is not really understanding everything about c. F. She she does now now that it is live show me that she does know that it cannot be kids. But things could be about to change scientists have proven for the 1st time ever that an experimental technique called gene therapy can improve the health of those with Cystic Fibrosis ive come into Central London to meet the doctors and the clinicians involved in the gene therapy trial and to Cystic Fibrosis. Western when they come to like adding literature. To stick fibrosis is as you know a genetically inherited disease parents who pass those copies on to their child and they have Cystic Fibrosis during the 1st year of life most babies will experience and lung problems and those relates to the buildup of sticky mucus within the airways and that sticky mucus attracts bacterial infections and the bacteria infections become chronic and they eventually cause quite significant lung scarring in the u. K. There are around 10000 people with Cystic Fibrosis at the moment on our registry about one in 22 of us is a carrier of the mutated gene most of us wont realise and about one in 2000 babies are born with Cystic Fibrosis the genetic nature of this and other conditions mean that treatment has focused on managing the symptoms as best as possible but a new and experimental technique called gene therapy replace the faulty gene with a functioning one this is the largest and the longest duration gene therapy trial using a liquid formulation for Cystic Fibrosis that has ever happened in. 216. 00 patients completed the protocol and took at least 9 over the course of the year and it was in that group which was defined as being the group we were going to look at that we saw a Significant Impact on lung function at the end of the year we can thank the patients and their families in earth because without patients like mary and her mother we just couldnt have completed this trial so were really grateful. These results would not have been possible without the perseverance of scientists who spent years developing the genes and. We started this program at the start it would be very easy for patients to just hand the Gene Research and if it gets to the right area into the right cells in that lung it turned out that was much more difficult so how are you getting this healthy new gene into the areas and to do the job of the song teaching. For the try that is just finished but actually using a very simple minded cure its a pet but we did just use the chin and we mixed it with this. This form smaller complex that complex then into the lungs of Cystic Fibrosis patients the dose of gene therapy that the trial participants received does not terminate correct the faulty Cystic Fibrosis d. N. A. But scientists are working on finding a longer lasting solution Clinical Trial results have been very encouraging but theyre not quite good enough to turn them into a treatment yet so we have plans for and as a trial where we get more there is some gene complexes and more frequently basically in addition to that we have to developed by wrists just very very efficient in getting genes into the lungs do you think you see the fires might be more efficient than using the static possibly using them and we certainly think so based on all. The evidence we have the virus is at least 140. 00 more effective fighting very frightening. These Success Stories represent a huge step forward for people might match did you notice any changes cheering the course of the treatment i thought i had no more injury i didnt need well though charity work a. Were christian tradition was back so i prayed still going up lets get a little more was done. And how does that make you feel when you submit cheating so mean that i make sure you get to know die i could die die could do and die now i can down the hope is that one day gene therapy will be approved for use and widely available to those with Cystic Fibrosis holders people that are studying and working to get this drug to work even better than it did its just pray they can get it done and they can get the funding and if it doesnt come soon enough mary shes helped other faithful if its not. The next generation of children born with Cystic Fibrosis in a city some are. Going to begin to say i sat on how corny next week. Is that really nice. Alum are back again. Things can stay. By the age of 85 nearly half of us will suffer from oxygen damage to the name which can lead to chronic pain and disability or perhaps because carthage unlike other tissues doesnt have its own blood supply. So heals very slowly. When im in hiroshima japan to meet the surgeon pioneering new techniques in regenerating on days. Professor mitchell or she is one of the worlds leading nice surgeons and a revered figure in the world of Regenerative Medicine. And the professor to be here. Ok thank you. Jay tech is an enterprise focusing on Tissue Engineering and has spent over 10 years commercializing professor archies research. Sort of saying yeah. Right nice to see how youre very welcome things are back. In 1000 for my dads on paper wasnt published by Swedish Group the swedish team had developed a way of regenerating cottage in a lab and then re injecting it in liquid form directly into the knee however there was a weak point all with the need. In order to solve this problem started to use the very same scale for the. Yes you can imagine that. The foot would be here coming up yes if that. Meniscus has no blood supply or if injury is the. Wrong we are blind to resect say what you can do with this Regenerative Medicine is to take the patients own cotton sheets from the same joint yes all the chain the confidence is essential company i see it this engineer the cuts. And thats why were here yeah just half a gram of healthy cartilage is harvested it is then broken down with enzymes and then planted on a college in scaffold designed by professor ought to after just 4 weeks the cells will have multiplied to form a 4 square centimeter disk. The surgeon then makes a template of the lesion and uses that to harvest some perry all still tissue from the shin bone. This will be the cover used to hold the new cartilage in place so this is a model of someones potentially regenerated cartilage but the beauty of it being the patients own cells here is that its not rejected you know any medicine from the viewpoint i mean in neurological reaction. Is a topic today this method has an almost 90 percent success rate and is considered a leading treatment fanie cartilage defects will what are the limitations of this can it be done better we need a larger scheme. That is invasive. Painful after surgery so less invasive technique is desired i have another new proceed youre using the magnetic. The goal was to devise a less invasive procedure. Much like the original idea of simply injecting the cartilage into the knee we inject so many serious. 10000000 serious we. Teach in the knee joint. The you see the injectors still cant see if inject cells blindly into the fluid nuptial they go all over and that made scarring so youd rather just close the where there is actually enjoy the right pinpoint targeting so how did you achieve that so i decided to use a small i am particle. To do that. Then come a stimson counterpart of small i am part of the action stem cells not the eye and can fuck all this then they can be controlled that direction with a strong month then my lord thats the most in the will magnetic force. From here theres an injection. Attaching to the defect the area is being channeled that way i can see it very clearly by some sort of trick of nature the stem cells like to swallow are not honest which is this whole procedure hinges on that because then you can manipulate. That solution of stem cells with a magnetic field. So not having to cut open the knee in any way you can attach those themselves to just the area where the cottage is broken down the different area how do you make them stay there is there a magnet on the skin just 10 minutes from the outside of the ski you are really a minute then he physically they start to be under here to the effect to your ear its amazing the bolotnaya this is a brand new. Only here. Japan is aiming to be at the forefront of Regenerative Medicine and scientists are researching possible treatments for previously incurable diseases such as liver cirrhosis retinal generation and even outsiders but a crucial hurdle for many stem cell therapies is positioning the cells within the body this is led some to call professor archies magnetic breakthrough an important step forward in Regenerative Medicine in 2015 this footage was shot by Japanese Television when professor archie performed the 1st ever magnetic cartilage restoration the patient was a semi professional tennis player and her cottage injury threatened to curtail her career. The procedure involves extracting some bone marrow to harvest stem cells after cultivation a few stem cells were injected and the magnets came out for the 1st time. A year on his back for a checkup. That morning and the. New. Sports. In the home of the q. I dont. Think. Its a. Company thats. Just. About i mean its a bit like the bullet train. And. Yeah. I go its ready for me which will reveal whether her wound has healed following the magnetic knee regeneration procedure. Here we go its ready. This potion. Repay out yes because this was a complete idiot area thats very much noticeably better yes what he 1st injected it that huge defect of redness and now its all white its covered in cottage now. It takes almost into who he is when i can see it with this idea. And so im very happy. Finished. At the moment professor all cheese technique is only applicable to relatively young knee joints but hes already working on ways to adapt it for older patients suffering from also off like to come 70 years old id like to walk with my knee joint so hes changing course here is a very very desirable so id like to provide. Your. Trying to seize is a parasitic illness that is found mainly in the poor Rural Regions of central and south america and it is estimated that in excess of 10000000 people are infected with the disease. I see and im in bolivia to meet a woman who may just have found a solution to this devastating disease. Diseases caused by the parasite. Which is carried by the triad to mean dog known locally as winter coats when an infected by someone leaves behind infected feces scratching the bite grabs the infected feces and. Once in the body the parasites multiply and spread. Lasts approximately 2 months causing my symptoms it then goes into remission and it can be decades later before the chronic stage begins where the parasite attacked the heart and it just of organs which can cause intestinal and cardiac disorders progressive destruction of the heart muscle can lead to Heart Failure and sudden death there is no vaccine. When i was there. Is an expert on the deadly vinci insect. That i meant they were in job. Loss. Last but i this. Is me that at this time of day we work be getting activity that. We had that. He were making less but its on us. Thats. Hes big they say she has got bottled up to this so i just take. A lot so. Make a little. How many intruders do you think are in this house than in the experience here youre going to rather know when i was really in the class he. Knows the meaning to guess. 1000 injured yeah. But. The pain and suffering caused by infection has a devastating impact on communities like the indictee of the 250 people that live there are brum estimates that up to 80 percent of chinas we need to. What has been the impact of childhood disease on your life and your families. Do you have a chance disease youre so. Thank. You. Its. Never some with. Me my dear. Theyre bankrupt but i but better than most. Of the past 15 years go to people who has been working into libya using an insecticidal paint to rid its infected communities of the bin to create insect tell me about his fire this is the paint you have developed to combat. But mrs morse of. You. In other words the new paint is an advance on previous insecticidal paints because the insecticides arm bedded with an microcaps which slowly released them over 2 to 4 years containing the insecticides like this means that the concentration of chemicals can be lower and that several different pesticides which dont work if they are mixed together can be used. Ok so do i have to dress up like that yes ok lets turn this theres nothing id like to do more than put an oval on in 35 degree heat. Which scholars this is going to look. For theyre. Not. Doing they are love thats right. Im. Sure were similar to some of this was for those posts. And then just. Ok. Currently each home costs approximately 200. 00 us dollars to pay with the Financial Support coming from various organizations and private donors. In the last 15 years. Have treated 6000 homes in 93 communities across the region which are home 224000 individuals incredibly the number of new cases of disease in these communities has dropped to almost 0. Is because. Oh yeah. Yeah this is it already so this is. Back to the house. With the inside and outside painted the house will be clear of the insects within 24 hours. Following its success fighting tigers disease the pain is now being used to come back thank you fever and malaria in communities and gone. Lives in one of the 1st villages the people are treated in bolivia. Can you. Describe to me what your house was lived before the painting was done. So with lots of interest in your house. Hey danny me a lot of those saw me he had and that chuckles free if i ask you have you know you asked me a lot of thought i left been good at the end. The diagnosis he has been sick for a long 6 months now the challenge ahead there when one of these 96 could be a new cure or a basis of a new cure all for colors on her illness or disability aljazeera examines priam meaning treatments so this is the explosive yes its basically a wearable robot like iraq revisited on aljazeera business updates brought to you by Qatar Airways going places together. Business updates brought to you by Qatar Airways going places together what went wrong in society that opened up the space on the right she is a european problem and thats not the palatable and its impossible for going to people by the school are. People ready trying to take. A lead that is profound a Strong Demand our song woman while getting the growth of rejectionism of this world because of all those of europes forbidden colony episode 2 on aljazeera. This is al jazeera. Hello im sam hes a this is the news hour live from doha coming up in the next 60 minutes a United States and democratic congresswoman fight back against whole big coal racist hate filled bullying by the u. S. President. We are grateful for your solidarity your encouragement and your support in the face of the most recent zina phobic bigoted remarks from the occupant